TAS 2 R Activation Promotes Airway Smooth Muscle Relaxation Despite β 2 - Adrenergic 1 Receptor Tachyphylaxis 2 3 Steven

TAS2R Activation Promotes Airway Smooth Muscle Relaxation Despite β2-Adrenergic 1 Receptor Tachyphylaxis 2 3 Steven S. An, Wayne C. H. Wang, Cynthia J. Koziol-White, Kwangmi Ahn, Danielle Y. 4 Lee, Richard C. Kurten, Reynold A. Panettieri, Jr., and Stephen B. Liggett 5 6 Program in Respiratory Biology and Lung Disease, Johns Hopkins University, Bloomberg 7 School of Public Health, Baltimore, MD 21205; Department of Medicine, University of 8 Maryland School of Medicine, Baltimore, MD 21201; Division of Pulmonary, Allergy and 9 Critical Care, Airways Biology Initiative, University of Pennsylvania Medical Center, 10 Philadelphia, PA 19104; National Institutes of Health, Bethesda, MD 20892; Department of 11 Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 12 72202; 6 Personalized Medicine Institute, University of South Florida Morsani College of 13 Medicine, Tampa, Fl 33612 14 15 *Contributed Equally 16 17 Running Head: Efficacy of a bitter tastant chloroquine in β2AR tachyphylaxis 18 19 Corresponding Author: 20 Steven S. An, Ph.D., Johns Hopkins University, Bloomberg School of Public Health, 615 N 21 Wolfe Street, Room E-7616, Baltimore, MD 21205. Tel (410) 502-5085, Fax (410) 955-0299, 22 Email [email protected] 23 24 Articles in PresS. Am J Physiol Lung Cell Mol Physiol (June 8, 2012). doi:10.1152/ajplung.00126.2012